Glutamate and GABA receptors in vertebrate glial cells
- 1 March 1991
- journal article
- review article
- Published by Springer Nature in Molecular Neurobiology
- Vol. 5 (1) , 31-43
Abstract
Glial cells of the central nervous system express receptors for the main inhibitory and excitatory neurotransmitters, GABA and glutamate. The glial GABA and glutamate receptors share many properties with the neuronal GABAA and kainate/quisqualate receptors, but are molecularly and, in some aspects, pharmacologically distinct from their neuronal counterparts. The functional role of these receptors is as yet speculative: They have been proposed to control proliferation of astrocytes, serve to balance ion changes at GABAergic synapses, or they could enable the glial cell to detect neuronal synaptic activity.Keywords
This publication has 57 references indexed in Scilit:
- Heterogeneity in the Membrane Current Pattern of Identified Glial Cells in the Hippocampal SliceEuropean Journal of Neuroscience, 1992
- GABA‐ and glutamate‐activated currents in glial cells of the mouse corpus callosum sliceJournal of Neuroscience Research, 1992
- Expression and Developmental Regulation of a GABAA Receptor in Cultured Murine Cells of the Oligodendrocyte LineageEuropean Journal of Neuroscience, 1991
- Glutamate‐Stimulated, Guanine Nucleotide‐Mediated Phosphoinositide Turnover in Astrocytes Is Inhibited by Cyclic AMPJournal of Neurochemistry, 1990
- Excitatory Amino Acids Stimulate Inositol Phospholipid Hydrolysis and Reduce Proliferation in Cultured AstrocytesJournal of Neurochemistry, 1990
- Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acidsNature, 1989
- GABA triggers a Cl− efflux from cultured mouse oligodendrocytesNeuroscience Letters, 1989
- Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytesGlia, 1989
- Glutamate opens Na+/K+ channels in cultured astrocytesGlia, 1988
- Glutamate Receptor Subtypes in Cultured Cerebellar Neurons: Modulation of Glutamate and γ‐Aminobutyric Acid ReleaseJournal of Neurochemistry, 1987