Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy
- 26 December 2006
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 67 (12) , 2253-2255
Abstract
We conducted a randomized, open-label, controlled trial to assess the efficacy of oxcarbazepine for prophylaxis against oxaliplatin-induced peripheral neuropathy (OxIN). Thirty-two patients with colon cancer received 12 courses of the FOLFOX-4 regimen and were randomly assigned to receive oxcarbazepine (600 mg BID) or chemotherapy without oxcarbazepine. The incidence of OxIN was strikingly decreased in patients receiving oxcarbazepine (31.2% vs 75%). Oxcarbazepine may prevent OxIN symptoms. Further larger placebo-controlled trials are warranted to confirm our results.Keywords
This publication has 7 references indexed in Scilit:
- Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage‐gated sodium channelsBritish Journal of Pharmacology, 2005
- Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II studyAnnals of Oncology, 2005
- What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs?Epilepsy & Behavior, 2004
- A Possible Explanation for a Neurotoxic Effect of the Anticancer Agent Oxaliplatin on Neuronal Voltage-Gated Sodium ChannelsJournal of Neurophysiology, 2001
- Inhibitory effect of oxcarbazepine on high-frequency firing in peripheral nerve fibersEuropean Journal of Pharmacology, 2001
- The chemotherapeutic oxaliplatin alters voltage-gated Na+ channel kinetics on rat sensory neuronsEuropean Journal of Pharmacology, 2000
- Total neuropathy scoreNeurology, 1999