A Molecular Marker for Chloroquine-Resistant Falciparum Malaria
Authors:
- Ogobara K. DoumboODOgobara K. Doumbo
- Joseph F. CorteseJCJoseph F. Cortese
- Kassoum KayentaoKKKassoum Kayentao
- Safi DoumboSDSafi Doumbo
- Yacouba DiourtéYDYacouba Diourté
- Drissa CoulibalyDCDrissa Coulibaly
- Alassane DickoADAlassane Dicko
- Xin-Zhuan SuXin-Zhuan Su
- Takashi NomuraTNTakashi Nomura
- David A. FidockDavid A. Fidock
- Thomas E. WellemsTWThomas E. Wellems
Top Cited Papers
Open Access
- 25 January 2001
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 344 (4) , 257-263
Abstract
Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively.Keywords
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