miR‐190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non‐coding RNA treRNA
Authors:
- 19 November 2015
- journal article
- Published by Wiley in FEBS Letters
- Vol. 589 (24PartB) , 4079-4087
Abstract
TreRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence treRNA post‐transcriptionally. Suppression of treRNA by miR‐190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR‐190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR‐190a–treRNA axis in hepatoma progression and shed light on lncRNA‐based cancer therapies for hepatoma patients at high risk of metastasis.Keywords
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