Arsenical C‐Glucoside Derivatives with Promising Antitumor Activity
- 22 June 2015
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2015 (21) , 4620-4623
Abstract
C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (AsIII), showed promising antiproliferative activity on a cell line of neuroblastoma (SK‐N‐BE).Keywords
This publication has 13 references indexed in Scilit:
- Organic Arsenicals As Efficient and Highly Specific Linkers for Protein/Peptide–Polymer ConjugationJournal of the American Chemical Society, 2015
- Regulation of cancer cell metabolismNature Reviews Cancer, 2011
- Synthesis of Naturally Occurring Arsenic-Containing CarbohydratesAustralian Journal of Chemistry, 2009
- Synthesis of C-Glycoconjugates from Readily Available Unprotected C-Allyl Glycosides by Chemoselective LigationJournal of Carbohydrate Chemistry, 2008
- (2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activityJournal of Organometallic Chemistry, 2006
- Transport of the new chemotherapeutic agent β- d -glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na + - d -glucose cotransporter SAAT1Proceedings of the National Academy of Sciences, 1998
- An efficient synthesis of anhydroalditols and allylic-glycosidesThe Journal of Organic Chemistry, 1987
- The synthesis of (R)-2′,3′-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-β-D-riboside, a naturally-occurring, arsenic-containing carbohydrateTetrahedron Letters, 1986
- Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysJournal of Immunological Methods, 1983
- THE METABOLISM OF TUMORS IN THE BODYJournal of General Physiology, 1927