Comparison of Cardiovascular Events Among Users of Different Classes of Antihypertension Medications

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Abstract
Hypertension is the most prevalent risk factor for mortality and disability-adjusted life-years1 worldwide. Cardiovascular disease remains the leading cause of death globally, accounting for 17.7 million deaths in 2015, which represented 31% of all deaths worldwide.2 Hypertension is an important factor in cardiovascular disease.3 In 2010, it was estimated that one-third of the world’s adult population had hypertension.4 The introduction of the American College of Cardiology and the American Heart Association hypertension guidelines in 2017 resulted in higher estimates of the number of people with hypertension.5,6 Knowledge of optimal first-line antihypertension medications for the prevention of cardiovascular events and mortality will be important for clinical decision-making. Moreover, the identification of treatments that are most effective for controlling hypertension and subsequent cardiovascular events and mortality and that have the least harmful effects is imperative to guide clinicians and decrease cardiovascular disease burdens worldwide.

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