From Screening to Mechanism-Informed Analysis: A Standardized High-Throughput Electrochemistry Platform for Redox Species Discovery

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Abstract
Systematic evaluation of redox-active molecules is central to the discovery of next-generation energy-storage chemistries, yet conventional electrochemical workflows remain limited by low throughput and poor cross-condition standardization. Here we present HT-EChem, a high- throughput electrochemical platform that integrates cyclic voltammetry (CV) with a 96 well plate format to enable rapid, reproducible measurements across large sample sets and controlled condition sweeps. HT-EChem operates at microliter-scale sample volumes, substantially reducing reagent consumption and enabling screening when material availability is limited. Using iron-aminopolycarboxylate complexes and representative organic redox molecules as model systems, the platform resolves pH-dependent shifts in redox potentials and changes in reversibility, enabling rapid construction of potential-pH maps and stability-pH profiles. High-density measurements distinguish ligand-dependent electrochemical behavior: Fe-PDTA exhibits dual reduction features consistent with an electrochemical-chemical (EC) sequence involving structural reorganization, whereas Fe-EDTA and Fe-DTPA show a single dominant reduction peak under comparable conditions. By combining automated sample handling with structured data processing, HT-EChem provides a scalable route to generate comparable electrochemical datasets for redox-material screening, mechanism-informed interpretation, and downstream computational analysis.
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