Electrospinning of biomimetic fibrous scaffolds for tissue engineering: a review
Authors:
- 9 July 2019
- journal article
- review article
- Published by Taylor & Francis in International Journal of Polymeric Materials and Polymeric Biomaterials
- Vol. 69 (15) , 947-960
Abstract
Fibrous microstructure has drawn extensive attention in tissue engineering due to its common presence in connective and muscle tissues. This paper reviews the latest advances in electrospinning as a nanofiber fabrication technique for biomimetic scaffolds. Specifically, we focus on scaffolds with gradients in element and structure, 3 D nanofiber scaffolds, and hydrogel scaffolds incorporated with nanofibers. Future directions of electrospinning research for tissue engineering are to realize the full potential of integrating the tunable 3 D fibrous microarchitecture in scaffold manufacturing at a clinically relevant scale, and to develop novel micro- and nano-scaffold architecture with modulated functionality for optimal tissue regeneration.Keywords
This publication has 146 references indexed in Scilit:
- The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibersBiomaterials, 2012
- Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signalsJournal of Biomedical Materials Research Part A, 2011
- An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defectsBiomaterials, 2011
- Three‐dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissuesJournal of Biomedical Materials Research Part A, 2010
- Material properties and osteogenic differentiation of marrow stromal cells on fiber-reinforced laminated hydrogel nanocompositesActa Biomaterialia, 2010
- Tissue Engineering Strategies for the Regeneration of Orthopedic InterfacesAnnals of Biomedical Engineering, 2010
- Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffoldBiomaterials, 2010
- Thin-film enhanced nerve guidance channels for peripheral nerve repairBiomaterials, 2009
- Scaffolding in tissue engineering: general approaches and tissue-specific considerationsEuropean Spine Journal, 2008
- The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibersBiomaterials, 2008