Calx, a Na-Ca exchanger gene ofDrosophila melanogaster
Open Access
- 16 September 1997
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 94 (19) , 10249-10254
Abstract
We have clonedCalx, a gene that encodes a Na-Ca exchanger ofDrosophila melanogaster.Calxencodes two repeated motifs,Calx-α andCalx-β, that overlap domains required for exchanger activity and regulation.Calxhas multiple transcripts in adults, including at least one expressed in the retina. TheCalxgenomic locus comprises ≥35 kb between theAtpαandrudimentary-likegenes in chromosomal region 93B. InXenopusoocytes, microinjectedCalxcRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+exchanger of mammalian heart. Implications ofCalx-α motifs for the mechanism of Na-Ca exchange are discussed.Keywords
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