Supplementary Figure S5 from Single-Cell RNA-seq Analysis Reveals Distinct Tumor and Immunosuppressive T-Cell Phenotypes in Patients with CLL Treated with Ibrutinib

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Supplemental Figure S5. Supporting data for Figure 3. A. Individual T and NK cell labels transferred via Seurat. B. T and NK cell subclusters. C. Proportion of reference cell type labels attributed to subclusters after aggregation. D. Classification of T and NK cell subclusters by differential representation analysis. E. Gene set enrichment analysis comparing the IBS-enriched CD4 TCM cluster to the IBR-enriched TCM cluster (top), and the IBS-enriched CD4 TCM cluster to the CD4 Naïve Cluster. Gene sets used were GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_UP and HALLMARK_TNFA_SIGNALING_VIA_NFKB, respectively. F. TCR diversity according to ibrutinib response and timepoint (Shannon’s Diversity; *: p < 0.05, Wilcoxon test).