Myocardial Toxicity of Contrast Agents Used in Angiography

Authors:
  • GGG G Gensini
    G G Gensini
  • SDS Digiorgi
    S Digiorgi
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Abstract
Although reports on the general, neurological, and renal toxicity of the more widely used triiodinated compounds for cardiovascular contrast studies are not infrequent (1, 19, 20), relatively little (3, 8, 15, 16, 18, 21) has been published regarding their specific myocardial toxicity, especially with reference to the ever-growing application of selective injection technics. Our increasing interest in these methods (6, 13), particularly in coronary arteriography (10, 12), and the reportedly frequent occurrence of inadvertent intra-myocardial injection (14, 23) induced us to undertake an experimental investigation of the myocardial toxicity of commonly used radiopaque agents. We proposed to select the contrast medium combining the advantages of satisfactory opacity with the lowest possible degree of myocardial toxicity. With this goal in mind, we developed the concept and standardized the technic of occlusion retrograde coronary venous injection, a previously unreported method affording the opportunity of ...