Covalent Small‐Molecule–RNA Complex Formation Enables Cellular Profiling of Small‐Molecule–RNA Interactions
- 1 August 2013
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 52 (38) , 10010-10013
Abstract
Won't let you go! A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by a factor of about 2500 but also enables cell‐wide profiling of its RNA targets.Keywords
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