CLINICAL DELIVERY SYSTEM FOR INTRA-PERITONEAL HYPERTHERMIC CHEMOTHERAPY

Authors:
  • JSJ S Spratt
    J S Spratt
  • RAR A Adcock
    R A Adcock
  • MMM Muskovin
    M Muskovin
  • WSW Sherrill
    W Sherrill
  • JMJ McKeown
    J McKeown
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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (2) , 256-260
    • PMID:6766084
Abstract
A 35 yr old man was treated for pseudomyxoma peritonei by surgery and by thermal infusion and chemotherapy with a machine designed specifically for the treatment of cancers of serosal surfaces. After extensive abdominal resection and closure, the patient''s peritoneal cavity was instilled with 2.5 l of 5% lactated Ringer''s solution. He was then attached to hyperthermic perfusion system which elevated the i.p. temperature by warming (to 42.degree.) and recirculating the effusion solution. When the 42.degree. i.p. temperature was attained (after 1.5 h), chemotherapy was added to the recirculating effusion. A 2nd procedure followed 8 days later. The patient''s postoperative course was uneventful except for minor pulmonary atelectasis with bacteremia. Hyperthermic perfusion was tolerated well and was evaluated as safe for intracavitary cancer treatment.