Human interleukin‐13 activates the interleukin‐4‐dependent transcription factor NF‐IL4 sharing a DNA binding motif with an interferon‐γ‐induced nuclear binding factor
Authors:
- Peter AlligerPAPeter Alliger
- Adrian MintyAMAdrian Minty
- Daniel CaputDCDaniel Caput
- Pascual FerraraPFPascual Ferrara
- Bärbel Höll-NeugebauerBHBärbel Höll-Neugebauer
- Gerti RankGRGerti Rank
- Ernst Peter RieberERErnst Peter Rieber
- 30 May 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 345 (2-3) , 187-192
Abstract
The effects of interleukin‐13 (IL‐13) and interleukin‐4 (IL‐4) on cellular functions were shown to be quite similar. We provide evidence that in monocytes as well as in T lymphocytes both IL‐4 and IL‐ 13 activate the same recently identified transcription factor NF‐IL4 which binds to the specific responsive element IL‐4RE. In addition, we show that a nuclear factor activated by interferon‐γ also interacts with the IL‐4RE. It differs from NF‐IL4 in the electrophoretic mobility of the complex with DNA, in its DNA‐binding specificity and in the proteins interacting with the DNA sequence. Sensitivity against various enzyme inhibitors suggests that components of the signal transduction pathway are shared by all three cytokines.Keywords
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