Membrane protein orientation and refinement using a knowledge-based statistical potential
Open Access
- 18 September 2013
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 14 (1) , 276
Abstract
Recent increases in the number of deposited membrane protein crystal structures necessitate the use of automated computational tools to position them within the lipid bilayer. Identifying the correct orientation allows us to study the complex relationship between sequence, structure and the lipid environment, which is otherwise challenging to investigate using experimental techniques due to the difficulty in crystallising membrane proteins embedded within intact membranes.Keywords
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