Characterization and potential applications of silver nanoparticles: an insight on different mechanisms
Open Access
- 11 July 2022
- journal article
- review article
- Published by Ural Federal University in Chimica Techno Acta
- Vol. 9 (4) , 20229402
Abstract
In the 21st century, a great interest is devoted to biomedical application of various nanoparticles, particularly, as a means of improving the effectiveness of therapy for different diseases. Silver nanoparticles (AgNPs) are the most studied and investigated type of nanoparticles. Due to the wide spectrum of their action, silver nanoparticles may be used both to influence pathogenic microorganisms and to improve the treatment of cancer. The basic physico-chemical characteristics and stabilizing agents play an important modifying role in the pharmacokinetics and pharmacodynamics of nanoparticles, determining the severity of the caused effect and their potential toxicity. This review summarizes the main physico-chemical properties of AgNPs and their impact on the biological effects. Additionally, biochemical and pathophysiological mechanisms of silver nanoparticles activity against various microorganisms and tumor cells are considered. Finally, we address the problems, associated with determining the optimal characteristics of nanoparticles, in order to increase their efficiency and reduce their toxicity for the macroorganism.Keywords
This publication has 195 references indexed in Scilit:
- Surface-Coating-Dependent Dissolution, Aggregation, and Reactive Oxygen Species (ROS) Generation of Silver Nanoparticles under Different Irradiation ConditionsEnvironmental Science & Technology, 2013
- Antibacterial effects of silver nanoparticles on gram-negative bacteria: Influence on the growth and biofilms formation, mechanisms of actionColloids and Surfaces B: Biointerfaces, 2013
- Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agentsParasitology Research, 2012
- Environmental Transformations of Silver Nanoparticles: Impact on Stability and ToxicityEnvironmental Science & Technology, 2012
- Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis propertiesNanotechnology, 2009
- Antiangiogenic properties of silver nanoparticlesBiomaterials, 2009
- Nanoparticle size and surface properties determine the protein corona with possible implications for biological impactsProceedings of the National Academy of Sciences, 2008
- Implications of silver nanoparticle induced cell apoptosis forin vitrogene therapyNanotechnology, 2008
- The bactericidal effect of silver nanoparticlesNanotechnology, 2005
- Nanoscale effects leading to non-Einstein-like decrease in viscosityNature Materials, 2003