Harnessing Biogenic Synthesis for Cuprous Oxide Nanoparticles Infused in a Dual Polymer Hydrogel for Wound Healing

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Abstract
Bacterial infections and delayed healing present significant impediments in wound care, making the development of hydrogels with both antibacterial and healing properties a promising solution for wound dressing. Nevertheless, creating such hydrogel dressings simply and efficiently remains a challenging endeavor. In this work, eco‐friendly cuprous oxide (Cu2O) nanoparticles using orange peel (Citrus sinensis) extract were synthesized. The synthesized Cu2O nanoparticles demonstrated excellent antioxidant and anti‐inflammatory properties compared to chemically synthesized Cu2O nanoparticles. Consequently, these nanoparticles were incorporated into a dual polymer hydrogel film via solution casting. As Cu2O nanoparticles were expected to increase mechanical and thermal stability, hydrogel films with different weight percentages of Cu2O nanoparticles were examined. The optimized hydrogel film demonstrated good swelling behavior, hemocompatibility, and potent antibacterial activity against gram‐positive and gram‐negative bacteria. Therefore, this study offers a facile and effective method for fabricating highly effective hydrogel dressings for wound healing.

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