Investigating the bioorthogonality of isocyanides
Open Access
- 15 December 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 62 (6) , 1945-1949
Abstract
Isocyanides have been explored as bioorthogonal triggers for uncaging reactions. However, our findings show they can covalently label proteins, indicating they may not be fully bioorthogonal in biological systems.Keywords
Funding Information
- AstraZeneca (CASE studentship)
- AstraZeneca (2883086)
- Biotechnology and Biological Sciences Research Council (BB/V003577/1)
- Biotechnology and Biological Sciences Research Council (BB/V003577/2)
- Austrian Science Fund (W1232)
- Engineering and Physical Sciences Research Council (Case Studentship 2883086)
- Engineering and Physical Sciences Research Council (EP/S031766/1)
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