SiCl 4 mediated one-pot synthesis of novel spirobibenzopyrans as potent anticancer agents
- 20 February 2019
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 43 (12) , 4669-4673
Abstract
This study is the first report on the anticancer activity of spirobibenzopyrans, an unexplored class of therapeutic agents. The synthesized spirobibenzopyrans were tested for anticancer activity across the NCI-60 cell-line panel. The in vitro and in silico results of the spirobibenzopyrans showed tremendous drug likeness scores as potential anticancer agents.Keywords
This publication has 17 references indexed in Scilit:
- Chemistry and Photochemistry of 2,6-Bis(2-hydroxybenzilidene)cyclohexanone. An Example of a Compound Following the Anthocyanins Network of Chemical ReactionsThe Journal of Physical Chemistry A, 2014
- New and unusual scaffolds in medicinal chemistryChemical Society Reviews, 2011
- DrugBank 3.0: a comprehensive resource for 'Omics' research on drugsNucleic Acids Research, 2010
- Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluationBioorganic & Medicinal Chemistry, 2004
- Spirobipyridopyrans and indolinospiropyridopyrans: Synthesis, x-ray crystal structure, separation of enantiomers, and barriers to thermal cleavage of the C(sp3)-O bondChirality, 2001
- Spirobinaphthopyrans: Synthesis, x-ray crystal structure, separation of enantiomers, and barriers to thermal racemizationChirality, 1999
- Chemistry of spiroketalsChemical Reviews, 1989
- Diastereoselective formation of chiral 2, 2′-spirobibenz[d]chromene derivatives. Evidence from circular dichroism and crystallographic dataTetrahedron, 1989
- Untersuchungen zur Quantenausbeute und Stabilität der Verfärbung von UV-empfindlichen Spiropyranschichten, die als Aufzeichnungsmaterial in optischen Datenspeichern verwendet werden / Investigations on the Quantum Yield and Stability of the Coloration of UV-Sensitive Spiropyran Layers Used as a Recording Material for Optical Data StorageZeitschrift für Naturforschung A, 1975
- Étude optique des états excités des spiropyrannes photochromiquesJournal de Chimie Physique et de Physico-Chimie Biologique, 1971