Bio‐Inspired Laccase‐Mimicking Cu 3 –MOF Nanozyme as Colorimetric Sensor Array for Rapid Degradation and Visual Sensing of Phenolic Compounds

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Abstract
Trinuclear copper complexes that emulate the active sites of multicopper oxidases (MCOs) are of broad biological interest. Here, a monoatomic‐node strategy combined with solvent reduction was used to construct a rare trinuclear copper MOF featuring a planar, equilateral‐triangular Cu I 0.6 Cu II 2.4 core. The Cu I 0.6 Cu II 2.4 –MOF nanozyme shows enzymatic activity 37.2 times than that of laccase and 13.6 times than that of a Cu II 3 –MOF analogue, retains high chemical stability from pH 4 to 12, and lowers production cost by 16.2‐fold relative to natural laccase. DFT calculations attribute the superior performance to the introduction of Cu + , which yields a more favorable electronic structure, reaction energy landscape, and intermediate binding than in Cu II 3 –MOF. Consequently, Cu I 0.6 Cu II 2.4 –MOF efficiently degrades phenolic pollutants and enables colorimetric discrimination and detection of 11 phenols as a colorimetric sensor array. It also affords sensitive detection of epinephrine and dopamine, with limits of detection of 6.5 and 10 µ m , respectively. Overall, this work demonstrates a laccase‐inspired route to high‐activity, low‐cost MOFs with strong potential for environmental remediation and biosensing.
Funding Information
  • Natural Science Foundation of Shandong Province (ZR2024ME072)
  • Natural Science Foundation of Shandong Province (ZR2021QB163)
  • National Natural Science Foundation of China (32501183)

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