Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications
Authors:
- 21 January 2020
- journal article
- review article
- Published by Wiley in Journal of the Chinese Chemical Society
- Vol. 67 (4) , 459-477
Abstract
Triazoles are nitrogen‐bearing heterocycles. In the last few decades, researchers have focused on fused heterocycles, as they have better pharmacological effect compared to triazoles alone. Among the two isomers of triazole, this article aims to explore the work carried out on 1,2,4‐triazole and N‐bridged heterocycles derived from 1,2,4‐triazole in last 18 years, highlight different synthetic pathways, and present a brief summary of the different biological activities possessed by 1,2,4‐triazole derivatives. The information collected in this article is expected to help researchers to discover novel therapeutic agents for better applications in the field of pharmaceutical science.Keywords
This publication has 68 references indexed in Scilit:
- Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studiesBioorganic & Medicinal Chemistry, 2012
- Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivativesEuropean Journal of Medicinal Chemistry, 2010
- Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agentsEuropean Journal of Medicinal Chemistry, 2010
- Synthesis and antitumor activity studies of some new fused 1,2,4-triazole derivatives carrying 2,4-dichloro-5-fluorophenyl moietyEuropean Journal of Medicinal Chemistry, 2009
- Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazolesEuropean Journal of Medicinal Chemistry, 2009
- New triazole and triazolothiadiazine derivatives as possible antimicrobial agentsEuropean Journal of Medicinal Chemistry, 2008
- Synthesis of some new substituted triazolo [4,3-a][1,4] benzodiazepine derivatives as potent anticonvulsantsEuropean Journal of Medicinal Chemistry, 2006
- Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivativesEuropean Journal of Medicinal Chemistry, 2004
- Synthesis of 4‐(pyrazol‐5‐yl)‐1,2,4‐triazole‐3‐thionesJournal of Heterocyclic Chemistry, 1998
- Synthesis of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1,2,4-triazol-3-yl)thio]acetic acids as possible superoxide scavengers and antiinflammatory agentsJournal of Medicinal Chemistry, 1984