Total Synthesis of (−)-Callystatin A
Authors:
- 11 August 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (18) , 3203-3206
Abstract
A convergent enantioselective synthesis of the natural product (−)-callystatin A (1) is described. Key features of the synthesis include a lipase-mediated kinetic resolution to install the C5 lactone stereochemistry, a hydrozirconation-based approach to the C8−C9 trisubstituted (Z)-olefin, and a stereoselective cross-coupling of a vinyl dibromide to install the C14−C15 trisubstituted (E)-olefin.Keywords
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