A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine) II. Isolation, physico-chemical properties and structure.
Authors:
- Hiroyuki OsadaHOHiroyuki Osada
- Masakazu UramotoMUMasakazu Uramoto
- Kiyoshi IsonoKIKiyoshi Isono
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (2) , 168-173
Abstract
RK-286C, a new inhibitor of protein kinase C, has been found by the bleb-forming assay using K562 cells. It was produced by Streptomyces sp. RK-286 and purified by solvent extraction, silica gel chromatography and preparative HPLC. Spectrometric analysis revealed that the structure is 4'-demethylamino-4'-hydroxystaurosporine.Keywords
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