Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia
Authors:
- Kathrine R TanKTKathrine R Tan
- Bonnie L KatalenichBKBonnie L Katalenich
- Kimberly E MaceKMKimberly E Mace
- Michael NamboziMNMichael Nambozi
- Steve M TaylorSTSteve M Taylor
- Steven R MeshnickSMSteven R Meshnick
- Ryan E WiegandRWRyan E Wiegand
- Victor ChalweVCVictor Chalwe
- Scott J FillerSFScott J Filler
- Mulakwa KamuliwoMKMulakwa Kamuliwo
- Allen S CraigACAllen S Craig
Open Access
- 9 June 2014
- journal article
- Published by Springer Nature in Malaria Journal
- Vol. 13 (1) , 227
Abstract
Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) decreases adverse effects of malaria during pregnancy. Zambia implemented its IPTp-SP programme in 2003. Emergence of SP-resistant Plasmodium falciparum threatens this strategy. The quintuple mutant haplotype (substitutions in N51I, C59R, S108N in dhfr and A437G and K540E in dhps genes), is associated with SP treatment failure in non-pregnant patients with malaria. This study examined efficacy of IPTp-SP and presence of the quintuple mutant among pregnant women in Mansa, Zambia.Keywords
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