Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.
Authors:
- M HurmeMHM Hurme
- P R ChandlerPCP R Chandler
- C M HetheringtonCHC M Hetherington
- E SimpsonESE Simpson
Open Access
- 1 March 1978
- journal article
- research article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 147 (3) , 768-775
Abstract
The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems that H-2-retricted anti-H-Y cytotoxic T cells are not responsible for the rejection of syngeneic male skin grafts.Keywords
This publication has 14 references indexed in Scilit:
- Responsiveness to HY Antigen Ir Gene Complementation and Target Cell SpecificityImmunological Reviews, 1977
- Y-antigen killing by T cells of women is restricted by HLANature, 1977
- Immune-response gene control of cytotoxic T-cell responses to H-Y.1977
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977
- Are there Y‐linked histocompatibility antigens in man?European Journal of Immunology, 1974
- Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity1974
- Genetics and Immunology of Sex-Linked Antigens1972
- THE GENETIC BASIS OF MALE SKIN REJECTION IN MICETransplantation, 1971
- ALLELIC FORMS OF A GENE CONTROLLING THE FEMALE IMMUNE RESPONSE TO THE MALE ANTIGEN IN MICETransplantation, 1971
- Passenger leukocytes and induction of allograft immunity.1971