Infrastructure for Sustainable Protein Innovation: A Global Value Chain Framework for CDMOs in Fermentation-Based Biomanufacturing

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Abstract
Achieving more sustainable production in emerging biomanufacturing sectors depends not only on technological innovation but also on how production systems are organized, governed, and scaled. Fermentation-derived proteins produced through biomass and precision fermentation offer promising pathways to reduce the environmental impacts of conventional livestock production. However, their sustainability and circularity outcomes depend heavily on access to biomanufacturing infrastructure and coordination along global value chains. Drawing on Global Value Chain (GVC) theory and an integrative review of more than 40 academic and industry sources published between 2017 and 2026, spanning global value chain governance, biomanufacturing scale-up, CDMO functions, and sustainability and bioeconomy transitions, this study develops a conceptual framework that positions Contract Development and Manufacturing Organizations (CDMOs) as key infrastructural intermediaries in fermentation-based protein systems. CDMOs facilitate access to fermentation capacity, technical expertise, and regulatory capabilities, thereby shaping governance arrangements, capability development, and the scaling of innovation. In doing so, they influence how cleaner production principles, such as resource efficiency, circular feedstock integration, and improved environmental performance, are translated into industrial practice. The analysis also highlights risks linked to CDMO-driven scaling, including infrastructure concentration, dependency dynamics, and unequal access across regions. By integrating GVC perspectives with insights from sustainability transitions and the circular bioeconomy, the article advances understanding of how infrastructural intermediaries shape cleaner production outcomes in emerging biomanufacturing value chains.

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