NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: the cost of fighting cancer with chemotherapy

Authors:
Publisher website
Google Scholar
Abstract
By combining acute and chronic muscle biopsies from patients with breast cancer with complementary in vitro experiments, we determined that breast cancer chemotherapy triggers a rapid skeletal muscle atrophy driven by NF-κB activation and subsequent upregulation of the ubiquitin-proteasome system. Importantly, sulfasalazine fully prevented muscle atrophy by mitigating the imbalance in protein turnover, offering promising perspectives for clinical translation and improving patient prognosis.
Funding Information
  • Institut Strauss
  • IdEx Unistra
  • ANR (ANR-10-INBS-0009)

This publication has 50 references indexed in Scilit: