Plasma norepinephrine variations with dietary sodium intake.

Authors:
  • MNM G Nicholls
    M G Nicholls
  • WKW Kiowski
    W Kiowski
  • AZA J Zweifler
    A J Zweifler
  • SJS Julius
    S Julius
  • MSM A Schork
    M A Schork
  • JGJ Greenhouse
    J Greenhouse
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Abstract
Plasma catecholamine and renin activity levels were measured across a range of dietary sodium intakes (10--300 mEq/day) in 20 normal male volunteers. Supine plasma norepinephrine levels presented a triphasic pattern in relation to urine sodium, whereas epinephrine levels were not significantly altered by sodium intake, and renin showed the well-known hyperbolic relationship to urine sodium excretion. Highest supine norepinephrine values occurred at low salt intakes, the lowest when sodium excretion was between 100 and 180 mEq/day, and intermediate when sodium excretion was greater than 180 mEq/day. These findings show that sodium intake is an important consideration in the interpretation of plasma norepinephrine levels.

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