3‐[11C]‐methyl‐D‐glucose, a potential agent for regional cerebral glucose utilization studies: Synthesis, chromatography and tissue distribution in mice

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Abstract
3‐[11C]‐Methyl‐D‐glucose was synthetized by methylation via 11CH3I of the potassium salt of diacetone‐D‐glucose; hydrolysis of the ketal groups with HCl yields 3‐[11C]‐methyl‐D‐glucose. The radiochemical yield is 35% at a specific activity of 1.9 mCi/μmole. Synthesis time including purification by hplc is about 30 min. Up to 12.0 mCi have been obtained in injectable solution.The tissue distribution of 3‐[11C]‐methyl‐D‐glucose was determined in mice at different times after an i.v. injection. All well‐perfused organs like lung, heart, liver, kidney and brain rapidly accumulate 3‐[11C]‐methyl‐D‐glucose. The accumulation in brain is significant: at 15 min after application it reaches 6.2% dose/g organ.

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