A suppressor T cell in the human mixed lymphocyte reaction.

Authors:
  • AMA J McMichael
    A J McMichael
  • TST Sasazuki
    T Sasazuki
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Abstract
Lymphocytes from an HL-A-B7 DW2 homozygous multiparous woman failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband and certain other homozygous typing cells. Her lymphocytes could suppress the response of HL-A matched responders to his. This effect was radiosensitive and due to a T [thymus-derived] cell. The suppressor cell showed antigen specificity.

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