Correlation of degradative rates of proteins with a parameter calculated from amino acid composition and subunit size.
Authors:
- F A MomanyFMF A Momany
- J J AguannoJAJ J Aguanno
- A R LarrabeeALA R Larrabee
- 1 September 1976
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (9) , 3093-3097
Abstract
A parameter is developed which relates the amino acid composition and subunit size of a protein to the degradative rate in vivo. This parameter was calculated for 11 rat liver proteins; a plot vs. the half-lives of these proteins is linear and has a coefficient of -0.96. Evidence suggests that the density of excess acidic amino acids on the surface of the protein is the most important factor in determining differential turnover.Keywords
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