Probing transient non-native states in amyloid beta fiber elongation by NMR
- 19 March 2019
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 55 (31) , 4483-4486
Abstract
Using NMR to probe transient binding of Aβ1–40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19–K28 and a lesser degree of interaction near the C-terminus (L34–G37).Keywords
Funding Information
- National Institute on Aging (AG048934)
- Council of Scientific and Industrial Research, India (02(0292)/17/EMR-II)
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