Transforming growth factor β exerts opposite effects from interleukin‐1β on cultured rabbit articular chondrocytes through reduction of interleukin‐1 receptor expression

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Abstract
Objective. The aim of the study was to determine whether transforming growth factor β (TGFβ) modulates the effects and the receptor expression of interleukin‐1 (IL‐1) in rabbit articular chondrocytes (RAC).Methods. Collagen, glycosaminoglycan, and collagenase production, together with 125I‐labeled IL‐1 binding, were analyzed in RAC cultures.Results. TGFβ reduced both IL‐1 effects on matrix metabolism and IL‐1 receptor expression.Conclusion. TGF/3 acts as an antagonist of the effects of IL‐1 through down‐regulation of its receptor expression.

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