M1 Macrophage Polarization Prevails in Epstein-Barr Virus-Infected Children in an Immunoregulatory Environment
- 12 January 2022
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 96 (1) , e0143421
Abstract
Most studies on Epstein Barr virus (EBV) primary infection have been performed in adolescents and young adult populations with Infectious Mononucleosis (IM) in developed countries. Furthermore, studies related to macrophage polarization were assessed in EBV-associated lymphomas, but little is known about macrophage polarization in the context of primary infection at the site of viral entry and replication, the tonsils.Keywords
Funding Information
- MINCyT | Agencia Nacional de Promoción Científica y Tecnológica (PICT 2015 1533, PICT 2017 1554, PICT 2018 0966)
This publication has 43 references indexed in Scilit:
- B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive ImmunityImmunity, 2012
- Epstein-Barr Virus Zta-Induced Immunomodulators from Nasopharyngeal Carcinoma Cells Upregulate Interleukin-10 Production from MonocytesJournal of Virology, 2011
- Macrophage Polarization in Health and DiseaseThe Scientific World Journal, 2011
- Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphomaHaematologica, 2010
- Germinal Center B Cells Latently Infected with Epstein-Barr Virus Proliferate Extensively but Do Not Increase in NumberJournal of Virology, 2010
- The Intersection of Epstein-Barr Virus with the Germinal CenterJournal of Virology, 2009
- The curious case of the tumour virus: 50 years of Burkitt's lymphomaNature Reviews Microbiology, 2008
- Cellular Responses to Viral Infection in Humans: Lessons from Epstein-Barr VirusAnnual Review of Immunology, 2007
- Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsilsLaboratory Investigation, 2005
- Cells Expressing the Epstein-Barr Virus Growth Program Are Present in and Restricted to the Naive B-Cell Subset of Healthy TonsilsJournal of Virology, 2000