Absorption of Radioactive Vitamin B12in Nonanemic Patients with Combined-System Disease
Authors:
- Irwin M. AriasIAIrwin M. Arias
- Leonard AptLALeonard Apt
- Myron PollycoveMPMyron Pollycove
- 8 December 1955
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 253 (23) , 1005-1010
Abstract
BEFORE the advent of liver or vitamin B12 treatment of pernicious anemia, approximately 80 per cent of patients who died of this disease had neurologic signs resulting from demyelinization of the posterior and lateral columns of the spinal cord.1 This neurologic disorder has been variously termed combined-system disease, posterolateral sclerosis, subacute combined degeneration of the spinal cord and funicular degeneration. Its pathology, clinical course and response to treatment are well kno-n.2 3 4 5 6 7 In vitamin B12 deficiency, anemia usually precedes the development of neurologic signs and symptoms, but occasionally this sequence is reversed and extensive neurologic damage may occur in . . .Keywords
This publication has 2 references indexed in Scilit:
- GASTRIC BIOPSY IN PERNICIOUS ANÆMIAMedical Journal of Australia, 1950
- Subacute Combined Degeneration of Spinal Cord without AnæmiaProceedings of the Royal Society of Medicine, 1928