(+)‐Tubocurarine is a potent inhibitor of cation channels in the vacuolar membrane of Chenopodium rubrum L
Authors:
- 17 December 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 277 (1-2) , 220-222
Abstract
The effect of the acetylcholine antagonist and channel blocker (+)‐tubocurarine on the calcium‐dependent slow vacuolar (SV) cation channels in the tonoplast of suspension‐cultured cells of Chenopodium rubrum L. was examined using the patch‐clamp technique. In whole‐vacuolar recordings the drug strongly suppressed the potassium conductance (EC50: 6 μM) and altered the kinetics of channel inactivation. In excised membrane patches (+)‐tuboeurarine evokes channel‐‘flickering’ without affecting the single‐channel conductance (approx. 80 pS).Keywords
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