Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease
Authors:
- 22 March 2005
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 64 (6) , 1081-1083
Abstract
8-Hydroxydeoxyguanosine (8-OHdG) has been used to evaluate oxidative stress. The authors investigated urinary 8-OHdG levels in 72 patients with Parkinson disease (PD) and in normal and disease control groups. The mean urinary 8-OHdG increased with the stage of PD and was not influenced by the current dose of DOPA. Our results suggest that urinary 8-OHdG is a potentially useful biomarker for evaluating the progression of PD.Keywords
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