Studies on aldose reductase inhibitors from natural products. Part III. Studies on aldose reductase inhibitors from medicinal plant of "Sinfito," Potentilla candicans, and further synthesis of their related compounds.
Authors:
- Mineo ShimizuMSMineo Shimizu
- Hajime NakayamaHNHajime Nakayama
- Masatoshi IshikuraMIMasatoshi Ishikura
- Yutaka UedaYUYutaka Ueda
- Kunihiro ImaiKIKunihiro Imai
- Akio SuzuiASAkio Suzui
- Naokata MoritaNMNaokata Morita
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Chemical and Pharmaceutical Bulletin
- Vol. 38 (10) , 2733-2736
Abstract
For several years we have screened natural products having aldose reductase (AR) inhibitory activity. 3,3',4-Tri-O-methylellagic acid 4'-sulfate potassium salt (2) was isolated from a Mexican herb "Sinfito" (Potentilla candicans) as a potent AR inhibitory active constituent. 2 was more potent (IC50 = 8.0 x 10(-8)M) than ellagic acid, which is one of the natural inhibitors of AR. So we examined the synthesis of ellagic acid derivatives and found that the sulfate group is one of the important function.Keywords
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