Utility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
Authors:
Open Access
- 28 August 2007
- journal article
- research article
- Published by Springer Nature in BMC Infectious Diseases
- Vol. 7 (1) , 99
Abstract
Interferon-gamma (IFN-γ) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with advanced HIV is unknown. We studied determinants of ELISPOT responses among patients with advanced HIV infection (but without active TB) living in a South African community with very high TB notification rates.Keywords
This publication has 33 references indexed in Scilit:
- Clinical, Immunological, and Epidemiological Importance of Antituberculosis T Cell Responses in HIV-Infected AfricansClinical Infectious Diseases, 2007
- Comparison of an Interferon-γ Release Assay with Tuberculin Skin Testing in HIV-infected IndividualsAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Undiagnosed Tuberculosis in a Community with High HIV PrevalenceAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Determinants of Mortality and Nondeath Losses from an Antiretroviral Treatment Service in South Africa: Implications for Program EvaluationClinical Infectious Diseases, 2006
- Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis controlAIDS, 2006
- Quantitative T Cell Assay Reflects Infectious Load of Mycobacterium tuberculosis in an Endemic Case Contact ModelClinical Infectious Diseases, 2005
- Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic reviewThe Lancet Infectious Diseases, 2004
- Effector and memory T-cell differentiation: implications for vaccine developmentNature Reviews Immunology, 2002
- Long‐Lived Immune Response to Early Secretory Antigenic Target 6 in Individuals Who Had Recovered from TuberculosisClinical Infectious Diseases, 2001
- A Mycobacterium tuberculosis operon encoding ESAT=6 and a novel low-molecular-mass culture filtrate protein (CFP-10)Microbiology, 1998