Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands
- 28 June 2018
- journal article
- research article
- Published by Wiley in European Journal of Inorganic Chemistry
- Vol. 2018 (26) , 3104-3112
Abstract
Organometallic N‐heterocyclic carbene (NHC) complexes with intercalating bis‐naphthalimide ligands were prepared and evaluated biologically. Cytotoxic effects against tumor cells or bacteria were strongly ligand dependent with minor influence of the metal (Ag, Ru, Rh, Au) centers. Complex 8b with a rhodium(I) NHC moiety was studied in more detail for its DNA interacting properties in comparison to the metal free ligand. These studies showed a good DNA binding pattern with some preference for the telomeric quadruplex structure hTelo. Complex 8b was also shown to trigger additional coordinative binding to the DNA and therefore represents an useful tool compound with a mixed intercalative/coordinative DNA binding mode.Keywords
Funding Information
- Seventh Framework Programme (609431)
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