Functional and morphological changes in post‐capillary venules in relation to lymphocytic infiltration into BCG‐induced granulomata in rat skin

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Abstract
Vessels identical to iymph node high endothelial venules (HEV) have been described in sites of non‐lymphoid tissue lymphocyte accumulation. In this study the function of these (HEV‐like) vessels has been investigated in BCG‐induced skin lesions in the rat. By following the traffic of radiolabelled lymphocytes from the blood into the lesions the HEV‐like vessels have been shown to be the preferred site of migration. The complicated development of the vessels has been studied and an hypothesis advanced to explain their inter‐relationship with tissue and circulating lymphocytes.

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