Parenteral Lipid Emulsions Based on Olive Oil Compared With Soybean Oil in Preterm (<28 Weeks' Gestation) Neonates: A Randomised Controlled Trial

Authors:
Publisher website
Google Scholar
Abstract
Background: New olive oil–based (OL) lipid emulsions (olive:soy oil = 4:1) have lower polyunsaturated fatty acid (PUFA) (20% vs 60%) and higher vitamin E content (an antioxidant) compared with traditional soybean oil (SO) emulsions.Objective: Compare efficacy and safety of OL with SO emulsions in preterm neonates (2‐isoprostanes (lipid peroxidation marker), plasma, and red blood cell fatty acids were measured before and after the study. Safety was monitored by liver function tests.Results: Forty‐four of 50 participants (OL‐23, SO‐21) completed the study. Both emulsions were well tolerated with no significant adverse events. F2‐isoprostane levels were comparable at baseline and study end. Oleic and linoleic acid levels were significantly high on day 6 in OL and SO groups, respectively. Long‐chain PUFA levels were similar between groups despite the lower PUFA content of OL. The olive oil–based group had significantly higher levels of C18:4n‐3, suggesting Δ6‐desaturase enzyme inhibition in the SO group.Conclusions: Olive oil–based emulsion was safe and well tolerated by preterm neonates. Similar long‐chain PUFA levels were achieved in the OL group despite significantly lower amount of PUFA content; however, there was no difference in lipid peroxidation (F2‐isoprostane levels). Large trials are needed to confirm these benefits.

This publication has 29 references indexed in Scilit: