Amyloid β-Targeted Metal Complexes for Potential Applications in Alzheimer's Disease
Authors:
- 5 February 2018
- journal article
- review article
- Published by Taylor & Francis in Future Medicinal Chemistry
- Vol. 10 (6) , 679-701
Abstract
Alzheimer's disease (AD) is currently an incurable neurodegenerative disorder that affects millions of people around the world. The aggregation of amyloid-β peptides (Aβ), one of the primary pathological hallmarks of AD, plays a key role in the AD pathogenesis. In this regard, Aβ aggregates have been considered as both biomarkers and drug targets for the diagnosis and therapy of AD. Various Aβ-targeted metal complexes have exhibited promising potential as anti-AD agents due to their fascinating physicochemical properties over the past two decades. This review classifies the complexes into three groups based on their potential applications in AD including therapy, diagnosis and theranosis. The recent representative examples are highlighted in terms of design rationale, working mechanism and potential applications. Graphical abstract Aβ-targeted metal complexes for potential applications in Alzheimer's disease.Keywords
This publication has 137 references indexed in Scilit:
- Development of Positron Emission Tomography β-Amyloid Plaque Imaging AgentsSeminars in Nuclear Medicine, 2012
- Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic DrosophilaPLOS ONE, 2012
- Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrilsNature Chemical Biology, 2011
- Design of small molecules that target metal-Aβ species and regulate metal-induced Aβ aggregation and neurotoxicityProceedings of the National Academy of Sciences, 2010
- Inhibition of Aβ42 Peptide Aggregation by a Binuclear Ruthenium(II)−Platinum(II) Complex: Potential for Multimetal Organometallics as Anti-amyloid AgentsACS Chemical Neuroscience, 2010
- Current applications and future potential for bioinorganic chemistry in the development of anticancer drugsDrug Discovery Today, 2009
- 18F Stilbenes and Styrylpyridines for PET Imaging of Aβ Plaques in Alzheimer’s Disease: A MiniperspectiveJournal of Medicinal Chemistry, 2009
- Multimodal techniques for diagnosis and prognosis of Alzheimer's diseaseNature, 2009
- Molecular Imaging of Cancer with Copper-64 Radiopharmaceuticals and Positron Emission Tomography (PET)Accounts of Chemical Research, 2009
- Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's diseaseProceedings of the National Academy of Sciences, 2008