A Comprehensive Survey on Bone Segmentation Techniques in Knee Osteoarthritis Research: From Conventional Methods to Deep Learning

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Abstract
Knee osteoarthritis (KOA) is a degenerative joint disease, which significantly affects middle-aged and elderly people. The majority of KOA is primarily based on hyaline cartilage change, according to medical images. However, technical bottlenecks such as noise, artifacts, and modality pose enormous challenges for an objective and efficient early diagnosis. Therefore, the correct prediction of arthritis is an essential step for effective diagnosis and the prevention of acute arthritis, where early diagnosis and treatment can assist to reduce the progression of KOA. However, predicting the development of KOA is a difficult and urgent problem that, if addressed, could accelerate the development of disease-modifying drugs, in turn helping to avoid millions of total joint replacement procedures each year. In knee joint research and clinical practice there are segmentation approaches that play a significant role in KOA diagnosis and categorization. In this paper, we seek to give an in-depth understanding of a wide range of the most recent methodologies for knee articular bone segmentation; segmentation methods allow the estimation of articular cartilage loss rate, which is utilized in clinical practice for assessing the disease progression and morphological change, ranging from traditional techniques to deep learning (DL)-based techniques. Moreover, the purpose of this work is to give researchers a general review of the currently available methodologies in the area. Therefore, it will help researchers who want to conduct research in the field of KOA, as well as highlight deficiencies and potential considerations in application in clinical practice. Finally, we highlight the diagnostic value of deep learning for future computer-aided diagnostic applications to complete this review.

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