Metal‐Free Radical Annulation‐Hydrofunctionalization of 1,6‐Enynes for Stereoselective Synthesis of (E)‐1‐Indanones
Authors:
- 29 April 2020
- journal article
- research article
- Published by Wiley in Asian Journal of Organic Chemistry
- Vol. 9 (7) , 1040-1044
Abstract
Two metal‐free radical annulation‐hydrofunctionalization cascades of 1,6‐enynes have been established, enabling the complete stereoselectivity to access a wide range of functionalized (E)‐1‐indanones with moderate to good yields. The reaction pathways involve in situ‐generated P‐ or S‐centered radical‐triggered α,β‐conjugated addition/5‐exo‐dig cyclization/H‐abstraction sequence, allowing direct and versatile protocols for stereoselective construction of 1‐indanone scaffolds with high functional group tolerance and wide substrate scope.Keywords
Funding Information
- National Natural Science Foundation of China (21971090)
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