Endocytosis of Polypeptides in Rabbit Nasal Respiratory Mucosa

Authors:
  • DCDario Cremaschi
    Dario Cremaschi
  • RGR Ghirardelli
    R Ghirardelli
  • SDSilvia Dossena
    Silvia Dossena
  • VRVilma Rossi
    Vilma Rossi
  • MPMario Pinza
    Mario Pinza
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Abstract
The nasal respiratory mucosa of the rabbit has a leaky epithelium actively transporting polypeptides by a specific transcytosis probably involved in sampling antigens. The transfer displays saturation kinetics and is abolished by metabolic inhibitors, actin filamet and microtubule disassemblers, inhibitors of vesicle fusion, and receptor recycling;it accepts polypeptide-covered but not uncovered nanoparticles.