The Role of Blood from HLA-Homozygous Donors in Fatal Transfusion-Associated Graft-versus-Host Disease after Open-Heart Surgery

Authors:
  • ASArie Shamiss
    Arie Shamiss
  • SOShlomit Orgad
    Shlomit Orgad
  • MHMonica Huszar
    Monica Huszar
  • NNNaomi Nussinovitch
    Naomi Nussinovitch
  • SMSimcha Meisel
    Simcha Meisel
  • EGEphraim Gazit
    Ephraim Gazit
  • ASAram Smolinsky
    Aram Smolinsky
Publisher website
Google Scholar
Abstract
Acute graft-versus-host disease has been described in immunocompromised patients receiving nonirradiated blood products.1 2 3 In addition to the involvement of the skin, liver, and gut typically seen in graft-versus-host disease after bone marrow transplantation,4 these patients have bone marrow involvement that results in pancytopenia. The aplasia observed in graft-versus-host disease is presumably due to recognition by the donor's immune-reactive cells of histoincompatible antigens on the host's hematopoietic precursor cells. Transfusion-associated graft-versus-host disease carries a high mortality rate; most patients succumb to infection.2 Because the onset of transfusion-associated graft-versus-host disease is delayed and because its symptoms are similar to those seen in . . .

This publication has 11 references indexed in Scilit: