Concise Total Synthesis of Isospongian Diterpenoid (±)‐Polyrhaphin D
- 5 July 2016
- journal article
- research article
- Published by Wiley in ChemistrySelect
- Vol. 1 (10) , 2225-2227
Abstract
The first total synthesis of isospongian diterpenoid (±)‐polyrhaphin D has been accomplished in 9 steps with 19 % overall yield starting from the Wieland–Miescher ketone derivative. The key features of our synthesis include a sequential reduction/Michael addition/aldol condenzation to assemble the A ring and an intramolecular dehydrative cyclization/olefin isomerization reaction to install the γ‐butenolide D ring.Keywords
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