Genetic studies of amyotrophic lateral sclerosis: Controversies and perspectives
Authors:
- 1 January 2009
- journal article
- research article
- Published by Taylor & Francis in Amyotrophic Lateral Sclerosis
- Vol. 10 (1) , 1-14
Abstract
The genetic causes of amyotrophic lateral sclerosis (ALS) are slowly being dissected out with the help of recent advances in genetic technology. Linkage studies and association studies examining candidate genes, candidate pathways, and genome-wide association have been used, based on direct sequencing and correlations between genetic variations. Copy number and microsatellite variants have also been examined, although the ideal methods for analysis are still being developed. In this review we examine the evidence for a genetic basis to ALS, discuss the challenges and difficulties faced and summarize the support for the reported genetic causes of ALS.Keywords
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