Ruthenium catalysed N-heterocyclisation: indoles from 2-aminophenethyl alcohols

Authors:
  • YTYasushi Tsuji
    Yasushi Tsuji
  • KHKeun-Tae Huh
    Keun-Tae Huh
  • YYYasuharu Yokoyama
    Yasuharu Yokoyama
  • YWYoshihisa Watanabe
    Yoshihisa Watanabe
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Abstract
Dichlorotris(triphenylphosphine)ruthenium is highly active as a catalyst for the N-heterocyclisation of 2-aminophenethyl alcohols (2a–d) into indole derivatives in toluene under reflux, and the reactions proceed with spontaneous hydrogen evolution.